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An arginine to glutamine mutation in residue 109 of human ornithine transcarbamylase completely abolishes enzymatic activity in Cos1 cells.

Ornithine transcarbamylase (OTC) is an important enzyme in the detoxification of ammonia to urea, and its deficiency is the most common inborn error of ureagenesis in humans. Among 24 cases of OTC deficiency previously examined, three unrelated individuals all showed loss of a Taq I site in the OTC...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Lee, J T, Nussbaum, R L
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1989
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304053/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2556444/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114360
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