Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism

The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and function. In some individuals serotonin reuptake inhibitors, which decrease pre-synaptic re-uptake of serotonin, can ameliorate symptoms, as can resperid...

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Main Authors: Ferdousy, Faiza, Bodeen, William, Summers, Kyle, Doherty, Olugbenga, Wright, O'Neil, Elsisi, Nahed, Hilliard, George, O'Donnell, Janis M., Reiter, Lawrence T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040417/
https://ncbi.nlm.nih.gov/pubmed/21147225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.12.001
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