Hepatocellular copper toxicity and its attenuation by zinc.

We studied the mechanisms by which excess copper exerts, and zinc mitigates, toxic effects on HepG2 cells. Survival and cell growth were reduced in media containing greater than 500 microM copper chloride for 48 h; LD50 was 750 microM. At 1,000 microM copper for 1 h, there was a general reduction of...

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Bibliografiske detaljer
Main Authors: Schilsky, M L, Blank, R R, Czaja, M J, Zern, M A, Scheinberg, I H, Stockert, R J, Sternlieb, I
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC304022/
https://ncbi.nlm.nih.gov/pubmed/2478589
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