Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease.

Individuals who are homozygous for the protease inhibitor phenotype Z (PiZ) genetic variant of alpha 1-antitrypsin (alpha 1-AT) have reduced plasma concentrations of alpha 1-AT, and are susceptible to premature development of pulmonary emphysema. A subset of this population develops chronic liver di...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Perlmutter, D H, Schlesinger, M J, Pierce, J A, Punsal, P I, Schwartz, A L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2553776/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114332
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