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Pathogenesis of Shigella diarrhea. XVI. Selective targetting of Shiga toxin to villus cells of rabbit jejunum explains the effect of the toxin on intestinal electrolyte transport.

To examine the mechanism by which Shiga toxin alters intestinal water and electrolyte transport, ligated loops of rabbit jejunum were incubated in vivo with purified toxin and then studied in vivo by single pass perfusion and in vitro by the Ussing chamber voltage-clamp technique. Toxin exposure led...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Principais autores: Kandel, G, Donohue-Rolfe, A, Donowitz, M, Keusch, G T
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1989
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304016/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2681267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114327
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