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Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

BACKGROUND: In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 × 2 factorial design. METH...

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Chi tiết về thư mục
Những tác giả chính:	Wolbers, Marcel, Heemskerk, Dorothee, Chau, Tran Thi Hong, Yen, Nguyen Thi Bich, Caws, Maxine, Farrar, Jeremy, Day, Jeremy
Định dạng:	Artigo
Ngôn ngữ:	Inglês
Được phát hành:	BioMed Central 2011
Những chủ đề:	Methodology
Truy cập trực tuyến:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3040154/ https://ncbi.nlm.nih.gov/pubmed/21288326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-26
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Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

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