Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

BACKGROUND: In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 × 2 factorial design. METH...

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Bibliographic Details
Main Authors: Wolbers, Marcel, Heemskerk, Dorothee, Chau, Tran Thi Hong, Yen, Nguyen Thi Bich, Caws, Maxine, Farrar, Jeremy, Day, Jeremy
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Methodology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040154/
https://ncbi.nlm.nih.gov/pubmed/21288326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-26
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