Modeling RNA interference in mammalian cells

BACKGROUND: RNA interference (RNAi) is a regulatory cellular process that controls post-transcriptional gene silencing. During RNAi double-stranded RNA (dsRNA) induces sequence-specific degradation of homologous mRNA via the generation of smaller dsRNA oligomers of length between 21-23nt (siRNAs). s...

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Bibliographic Details
Main Authors: Cuccato, Giulia, Polynikis, Athanasios, Siciliano, Velia, Graziano, Mafalda, di Bernardo, Mario, di Bernardo, Diego
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040133/
https://ncbi.nlm.nih.gov/pubmed/21272352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-19
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