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Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse
Defective melanocortin signaling causes hyperphagic obesity in humans and the melanocortin-4 receptor knockout mouse (MC4R(−/−)). The human disease most commonly presents, however, as haploinsufficiency of the MC4R. This study validates the MC4R(+/−) mouse as a model of the human disease in that, li...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Endocrine Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3040060/ https://ncbi.nlm.nih.gov/pubmed/21239438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0716 |
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