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Triplex targeting of human PDGF-B (c-sis, proto-oncogene) promoter specifically inhibits factors binding and PDGF-B transcription

Human c-sis/PDGF-B proto-oncogene has been shown to be overexpressed in a large percentage of human tumor cells establishing a growth-promoting, autocrine growth circuit. Triplex forming oligonucleotides (TFOs) can recognize and bind sequences in duplex DNA, and have received considerable attention...

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Udgivet i:Nucleic Acids Res
Principais autores: Liu, Jing, Xu, Ren-Huan, Jin, You-Xin, Wang, De-Bao
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30399/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160902/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.3.783
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