Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells

Hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by recurrent staphylococcal infections and atopic dermatitis associated with elevated serum IgE levels. Although defective differentiation of IL-17–producing CD4(+) T cells (Th17) partly accounts for the susceptibility to staphylo...

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Hoofdauteurs: Saito, Masako, Nagasawa, Masayuki, Takada, Hidetoshi, Hara, Toshiro, Tsuchiya, Shigeru, Agematsu, Kazunaga, Yamada, Masafumi, Kawamura, Nobuaki, Ariga, Tadashi, Tsuge, Ikuya, Nonoyama, Shigeaki, Karasuyama, Hajime, Minegishi, Yoshiyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039860/
https://ncbi.nlm.nih.gov/pubmed/21300911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100799
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