Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

Autophagy, an intracellular system for delivering portions of cytoplasm and damaged organelles to lysosomes for degradation/recycling, plays a role in many physiological processes and is disturbed in many diseases. We recently provided evidence for the role of autophagy in Pompe disease, a lysosomal...

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Bibliografiske detaljer
Main Authors: Raben, Nina, Schreiner, Cynthia, Baum, Rebecca, Takikita, Shoichi, Xu, Sengen, Xie, Tao, Myerowitz, Rachel, Komatsu, Masaaki, Van Der Meulen, Jack H, Nagaraju, Kanneboyina, Ralston, Evelyn, Plotz, Paul H
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2010
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039718/
https://ncbi.nlm.nih.gov/pubmed/20861693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.6.8.13378
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