Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune res...

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Autors principals: Quakkelaar, Esther D., Redeker, Anke, Haddad, Elias K., Harari, Alexandre, McCaughey, Stella Mayo, Duhen, Thomas, Filali-Mouhim, Abdelali, Goulet, Jean-Philippe, Loof, Nikki M., Ossendorp, Ferry, Perdiguero, Beatriz, Heinen, Paul, Gomez, Carmen E., Kibler, Karen V., Koelle, David M., Sékaly, Rafick P., Sallusto, Federica, Lanzavecchia, Antonio, Pantaleo, Giuseppe, Esteban, Mariano, Tartaglia, Jim, Jacobs, Bertram L., Melief, Cornelis J. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039654/
https://ncbi.nlm.nih.gov/pubmed/21347234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016819
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