Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells

BACKGROUND: Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of oligodendroglial progenitor cells (OPCs), suggesting that IFNγ i...

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Hauptverfasser: Horiuchi, Makoto, Itoh, Aki, Pleasure, David, Ozato, Keiko, Itoh, Takayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039583/
https://ncbi.nlm.nih.gov/pubmed/21261980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-8
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