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Targeting selenium metabolism and selenoproteins: Novel avenues for drug discovery
Selenoproteins play a wide range of roles in metabolism and oxidative stress defense and are produced by organisms in all three domains of life. Recent evidence has been presented that metal based cancer drugs target the selenol nucleophile of the active site selenocysteine in thioredoxin reductase...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039543/ https://ncbi.nlm.nih.gov/pubmed/21069141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b917141j |
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