Selective expression of a normal action of the 1,25-dihydroxyvitamin D3 receptor in human skin fibroblasts with hereditary severe defects in multiple actions of that receptor.

We evaluated three actions of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] in human skin fibroblasts to test for heterogeneity in hormone-response coupling. In fibroblasts from normal subjects the 1,25-(OH)2D3 concentrations for half-maximal effect (EC50) were: for mitogenic effect 0.0001-0.0005 nM,...

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Detalhes bibliográficos
Main Authors: Barsony, J, McKoy, W, DeGrange, D A, Liberman, U A, Marx, S J
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303936/
https://ncbi.nlm.nih.gov/pubmed/2542381
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