Development and Characterization of High Affinity Leptins and Leptin Antagonists

Leptin is a pleiotropic hormone acting both centrally and peripherally. It participates in a variety of biological processes, including energy metabolism, reproduction, and modulation of the immune response. So far, structural elements affecting leptin binding to its receptor remain unknown. We empl...

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Bibliographic Details
Main Authors: Shpilman, Michal, Niv-Spector, Leonora, Katz, Meirav, Varol, Chen, Solomon, Gili, Ayalon-Soffer, Michal, Boder, Eric, Halpern, Zamir, Elinav, Eran, Gertler, Arieh
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039357/
https://ncbi.nlm.nih.gov/pubmed/21119198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196402
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