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Impact of the N5-proximal Asn on the Thermodynamic and Kinetic Stability of the Semiquinone Radical in Photolyase

Flavoproteins can dramatically adjust the thermodynamics and kinetics of electron transfer at their flavin cofactor. A versatile regulatory tool is proton transfer. Here, we demonstrate the significance of proton-coupled electron transfer to redox tuning and semiquinone (sq) stability in photolyases...

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Detalhes bibliográficos
Main Authors: Damiani, Michael J., Nostedt, Jordan J., O'Neill, Melanie A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039355/
https://ncbi.nlm.nih.gov/pubmed/21131361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194696
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