Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors

Purpose: Sodium stibogluconate (SSG), a small molecule inhibitor of protein tyrosine phosphatases, combined with IFN-alpha-2b (IFN-α) inhibited solid tumor cell line growth in vitro. We conducted a phase I clinical trial with SSG plus IFN-α in advanced cancer patients to assess tolerance, maximum to...

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Detalhes bibliográficos
Main Authors: Naing, Aung, Reuben, James M., Camacho, Luis H., Gao, Hui, Lee, Bang-Ning, Cohen, Evan N., Verschraegen, Claire, Stephen, Saneese, Aaron, Joann, Hong, David, Wheler, Jennifer, Kurzrock, Razelle
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039225/
https://ncbi.nlm.nih.gov/pubmed/21326629
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