Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis

BACKGROUND: Hearing loss is a frequent long-term complication of pneumococcal meningitis (PM). Its main pathological correlate is damage to the organ of Corti and loss of spiral ganglion neurons. The only current treatment option is cochlear implants which require surviving neurons. Here, we investi...

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Main Authors: Demel, Cornelia, Hoegen, Tobias, Giese, Armin, Angele, Barbara, Pfister, Hans-Walter, Koedel, Uwe, Klein, Matthias
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038911/
https://ncbi.nlm.nih.gov/pubmed/21261959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-7
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