Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.

To improve our understanding of the metabolic role of cytokines in protein wasting, we estimated the rates of protein synthesis and degradation in muscle and liver tissues in intact rats treated with several doses of recombinant IL 1 and/or tumor necrosis factor (TNF)/cachectin. Protein breakdown in...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Flores, E A, Bistrian, B R, Pomposelli, J J, Dinarello, C A, Blackburn, G L, Istfan, N W
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1989
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303868/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2785120/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114059
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