A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting

A single-chain triplebody (sctb) 33-ds16-ds19 comprising two distal single-chain Fv fragments (scFvs) specific for the lymphoid antigen CD19 and the myeloid antigen CD33 flanking a central scFv specific for CD16, which is the low affinity Fc-receptor (FcγRIII) present on natural killer cells and mac...

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Detalhes bibliográficos
Principais autores: Schubert, Ingo, Kellner, Christian, Stein, Christoph, Kügler, Markus, Schwenkert, Michael, Saul, Domenica, Mentz, Kristin, Singer, Heiko, Stockmeyer, Bernhard, Hillen, Wolfgang, Mackensen, Andreas, Fey, Georg H
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038008/
https://ncbi.nlm.nih.gov/pubmed/21081841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.1.14057
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