Metabolism of Levulinate in Perfused Rat Livers and Live Rats: CONVERSION TO THE DRUG OF ABUSE 4-HYDROXYPENTANOATE

Calcium levulinate (4-ketopentanoate) is used as an oral and parenteral source of calcium. We hypothesized that levulinate is converted in the liver to 4-hydroxypentanoate, a new drug of abuse, and that this conversion is accelerated by ethanol oxidation. We confirmed these hypotheses in live rats,...

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Detalhes bibliográficos
Main Authors: Harris, Stephanie R., Zhang, Guo-Fang, Sadhukhan, Sushabhan, Murphy, Anne M., Tomcik, Kristyen A., Vazquez, Edwin J., Anderson, Vernon E., Tochtrop, Gregory P., Brunengraber, Henri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037702/
https://ncbi.nlm.nih.gov/pubmed/21126961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196808
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