TGFβ Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

Transforming growth factor-β (TGFβ) binding to its receptor leads to intracellular phosphorylation of Smad2 and Smad3, which oligomerize with Smad4. These complexes accumulate in the nucleus and induce gene transcription. Here we describe mitogen- and stress-activated kinase 1 (MSK1) as an antagonis...

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Main Authors: van der Heide, Lars P., van Dinther, Maarten, Moustakas, Aristidis, ten Dijke, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037612/
https://ncbi.nlm.nih.gov/pubmed/21106525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167379
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