Signaling Network Triggers and Membrane Physical Properties Control the Actin Cytoskeleton-Driven Isotropic Phase of Cell Spreading

Cell spreading is regulated by signaling from the integrin receptors that activate intracellular signaling pathways to control actin filament regulatory proteins. We developed a hybrid model of whole-cell spreading in which we modeled the integrin signaling network as ordinary differential equations...

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Autores principales: Rangamani, Padmini, Fardin, Marc-Antoine, Xiong, Yuguang, Lipshtat, Azi, Rossier, Olivier, Sheetz, Michael P., Iyengar, Ravi
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2011
Materias:
Cellular Biophysics and Electrophysiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037558/
https://ncbi.nlm.nih.gov/pubmed/21320428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.12.3732
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