NrCAM Deletion Causes Topographic Mistargeting of Thalamocortical Axons to the Visual Cortex and Disrupts Visual Acuity

NrCAM is a neural cell adhesion molecule of the L1 family that has been linked to autism spectrum disorders, a disease spectrum in which abnormal thalamocortical connectivity may contribute to visual processing defects. Here we show that NrCAM interaction with neuropilin-2 (Npn-2) is critical for se...

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Main Authors: Demyanenko, Galina P., Riday, Thorfinn T., Tran, Tracy S., Dalal, Jasbir, Darnell, Eli P., Brennaman, Leann H., Sakurai, Takeshi, Grumet, Martin, Philpot, Benjamin D., Maness, Patricia F.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037548/
https://ncbi.nlm.nih.gov/pubmed/21273439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4467-10.2011
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