New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in Sister Chromatid Cohesion

Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilize...

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Detalhes bibliográficos
Main Authors: Gellon, Lionel, Razidlo, David F., Gleeson, Olive, Verra, Lauren, Schulz, Danae, Lahue, Robert S., Freudenreich, Catherine H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037408/
https://ncbi.nlm.nih.gov/pubmed/21347277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001298
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