Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

The relationships between extracellular pH (pHo), intracellular pH (pHi), and loss of cell viability were evaluated in cultured rat hepatocytes after ATP depletion by metabolic inhibition with KCN and iodoacetate (chemical hypoxia). pHi was measured in single cells by ratio imaging of 2',7'-biscarbo...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Gores, G J, Nieminen, A L, Wray, B E, Herman, B, Lemasters, J J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113896
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