Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

The relationships between extracellular pH (pHo), intracellular pH (pHi), and loss of cell viability were evaluated in cultured rat hepatocytes after ATP depletion by metabolic inhibition with KCN and iodoacetate (chemical hypoxia). pHi was measured in single cells by ratio imaging of 2',7'-biscarbo...

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Pubblicato in:	J Clin Invest
Autori principali:	Gores, G J, Nieminen, A L, Wray, B E, Herman, B, Lemasters, J J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113896
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