Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis

BACKGROUND: Sterol biosynthesis is an essential pathway for fungal survival, and is the biochemical target of many antifungal agents. The antifungal drugs most widely used to treated fungal infections are compounds that inhibit cytochrome P450-dependent C14α-demethylase (CYP51), but other enzymes of...

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Detalhes bibliográficos
Main Authors: Ishida, Kelly, Fernandes Rodrigues, Juliany Cola, Cammerer, Simon, Urbina, Julio A, Gilbert, Ian, de Souza, Wanderley, Rozental, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036746/
https://ncbi.nlm.nih.gov/pubmed/21255433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-0711-10-3
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