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Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells.

The effect of tumor-promoting phorbol esters on the in vitro proliferation of mouse pluripotent hematopoietic stem cells (CFU-S) was examined using a short-term in vitro culture system and an 11-d spleen colony assay. Phorbol myristate acetate (PMA, 10(-7) M), but not the inert compound phorbol, sup...

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Published in:J Clin Invest
Main Authors: Spivak, J L, Hogans, B B, Stuart, R K
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303649/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2463264/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113844
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