In vitro mutagenesis of HLA-B27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes.

The HLA class I molecules identified serologically as HLA-B27 are highly associated with ankylosing spondylitis and related human disorders. All known HLA-B27 amino acid sequences contain a cysteine residue at position 67; no other published HLA class I sequence contains a cysteine within the hyperv...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Taurog, J D, el-Zaatari, F A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2458390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113708
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