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Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis. Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (JAK2), Myeloproliferative Leukemia...
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| Format: | Artigo |
| Jezik: | Inglês |
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Nature Publishing Group
2010
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035972/ https://ncbi.nlm.nih.gov/pubmed/20428194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.69 |
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