Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred.

Heterozygous hypobetalipoproteinemia is characterized by reduced plasma concentrations of LDL cholesterol, total triglycerides, and apo B to less than 50% of normal values. The molecular basis of this disorder remains unknown. The phenotype cosegregates with a DNA haplotype of the apo B gene in an I...

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Hlavní autoři: Leppert, M, Breslow, J L, Wu, L, Hasstedt, S, O'Connell, P, Lathrop, M, Williams, R R, White, R, Lalouel, J M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1988
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC303592/
https://ncbi.nlm.nih.gov/pubmed/2901434
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