Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis

GRASP65 (Golgi reassembly and stacking protein of 65 KDa) is a cis-Golgi protein with roles in Golgi structure, membrane trafficking and cell signalling. It is cleaved by caspase-3 early in apoptosis, promoting Golgi fragmentation. We now show that cleavage is needed for Fas-mediated apoptosis: expr...

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Detalhes bibliográficos
Main Authors: Cheng, J P X, Betin, V M S, Weir, H, Shelmani, G M A, Moss, D K, Lane, J D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035901/
https://ncbi.nlm.nih.gov/pubmed/21368855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.59
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