Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase-dependent pathway involving cytosolic acidification and alkalinization of tumour pH. In this paper, we further investigated the mecha...

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Autors principals: Marino, M L, Fais, S, Djavaheri-Mergny, M, Villa, A, Meschini, S, Lozupone, F, Venturi, G, Della Mina, P, Pattingre, S, Rivoltini, L, Codogno, P, De Milito, A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035900/
https://ncbi.nlm.nih.gov/pubmed/21368860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.67
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