Allosteric regulation of the primase (DnaG) activity by the clamp-loader (τ) in vitro

During DNA replication the helicase (DnaB) recruits the primase (DnaG) in the replisome to initiate the polymerization of new DNA strands. DnaB is attached to the τ subunit of the clamp-loader that loads the β clamp and interconnects the core polymerases on the leading and lagging strands. The τ–Dna...

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Bibliographic Details
Main Authors: Chintakayala, Kiran, Machón, Cristina, Haroniti, Anna, Larson, Marilyn A., Hinrichs, Steven H., Griep, Mark A., Soultanas, Panos
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035870/
https://ncbi.nlm.nih.gov/pubmed/19415803
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