Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

Inhibition of cholesterol synthesis by 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoAR) inhibitors has been associated with an increase in intestinal cholesterol absorption. This study examined how HMG-CoAR inhibition by atorvastatin modulates expression of key genes involved in intestinal choles...

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Main Authors: Tremblay, André J., Lamarche, Benoît, Lemelin, Valéry, Hoos, Lizbeth, Benjannet, Suzanne, Seidah, Nabil G., Davis, Harry R., Couture, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2011
Fag:
Patient-Oriented and Epidemiological Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035692/
https://ncbi.nlm.nih.gov/pubmed/21123766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M011080
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