Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry

Progress in understanding the biology of protein fatty acylation has been impeded by the lack of rapid direct detection and identification methods. We first report that a synthetic ω-alkynyl-palmitate analog can be readily and specifically incorporated into GAPDH or mitochondrial 3-hydroxyl-3-methyl...

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Autors principals: Yap, Megan C., Kostiuk, Morris A., Martin, Dale D. O., Perinpanayagam, Maneka A., Hak, Pieter G., Siddam, Anjaiah, Majjigapu, Janaki R., Rajaiah, Gurram, Keller, Bernd O., Prescher, Jennifer A., Wu, Peng, Bertozzi, Carolyn R., Falck, John R., Berthiaume, Luc G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2010
Matèries:
Methods
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035521/
https://ncbi.nlm.nih.gov/pubmed/20028662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D002790
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