Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

We investigated the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the resistance of dyslipidemic hamsters to statin-induced LDL-cholesterol (LDL-C) reduction and the molecular mechanism by which statins modulated PCSK9 gene expression in vivo. We utilized the fructose diet-induced...

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Detalhes bibliográficos
Main Authors: Dong, Bin, Wu, Minhao, Li, Hai, Kraemer, Fredric B., Adeli, Khosrow, Seidah, Nabil G., Park, Sahng Wook, Liu, Jingwen
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035512/
https://ncbi.nlm.nih.gov/pubmed/20048381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M003566
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