A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI

Plasma HDL cholesterol levels (HDL-C) are an independent predictor of coronary artery disease (CAD). We have completed a genome-wide linkage scan for HDL-C in a US cohort consisting of 388 multiplex families with premature CAD (GeneQuest). The heritability of HDL-C in GeneQuest was 0.37 with gender...

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Detalhes bibliográficos
Main Authors: Yang, Rong, Li, Lin, Seidelmann, Sara Bretschger, Shen, Gong-Qing, Sharma, Sonia, Rao, Shaoqi, Abdullah, Kalil G., MacKinlay, Kenneth G., Elston, Robert C., Chen, Qiuyun, Topol, Eric J., Wang, Qing Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035507/
https://ncbi.nlm.nih.gov/pubmed/20075193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004325
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