Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (–)-epigallocatechin-3-gallate

Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well understood, aggregation of Aβ is known to cause toxicity to neurons. Our recent study demonstrated the ability for oligomeric Aβ to stim...

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Autori principali: He, Yan, Cui, Jiankun, Lee, James C-M, Ding, Shinghua, Chalimoniuk, Malgorzata, Simonyi, Agnes, Sun, Albert Y, Gu, Zezong, Weisman∥, Gary A, Gibson Wood, W, Sun, Grace Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Neurochemistry 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035478/
https://ncbi.nlm.nih.gov/pubmed/21434871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100025
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