Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

The generation of insulin-producing β-cells from human pluripotent stem cells is dependent on efficient endoderm induction and appropriate patterning and specification of this germ layer to a pancreatic fate. In this study, we elucidated the temporal requirements for TGFβ family members and canonica...

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Autori principali: Nostro, M. Cristina, Sarangi, Farida, Ogawa, Shinichiro, Holtzinger, Audrey, Corneo, Barbara, Li, Xueling, Micallef, Suzanne J., Park, In-Hyun, Basford, Christina, Wheeler, Michael B., Daley, George Q., Elefanty, Andrew G., Stanley, Edouard G., Keller, Gordon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2011
Soggetti:
Development and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035090/
https://ncbi.nlm.nih.gov/pubmed/21270052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.055236
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