Different Influences on Tacrolimus Pharmacokinetics by Coadministrations of Zhi Ke and Zhi Shi in Rats

Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomicall...

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Detalhes bibliográficos
Main Authors: Lin, Shiuan-Pey, Wu, Ping-Ping, Hou, Yu-Chi, Tsai, Shang-Yuan, Wang, Meng-Ju, Fang, Shih-Hua, Chao, Pei-Dawn Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035000/
https://ncbi.nlm.nih.gov/pubmed/21318106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/751671
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