CNS-targeted Viral Delivery of G-CSF in an Animal Model for ALS: Improved Efficacy and Preservation of the Neuromuscular Unit

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motoneurons. We have recently uncovered a new neurotrophic growth factor, granulocyte-colony stimulating factor (G-CSF), which protects α-motoneurons, improves functional outcome, and increa...

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Main Authors: Henriques, Alexandre, Pitzer, Claudia, Dittgen, Tanjew, Klugmann, Matthias, Dupuis, Luc, Schneider, Armin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034860/
https://ncbi.nlm.nih.gov/pubmed/21139572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.271
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