Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIII heavy chain.

We have localized the binding region of a previously described monoclonal anti-factor VIII (FVIII) inhibitory antibody (C5) to amino acid residues Thr351-Ser365 of the thrombin-generated 54-kD fragment of the heavy chain of FVIII. Synthetic FVIII peptides were examined for the ability to competitive...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Foster, P A, Fulcher, C A, Houghten, R A, de Graaf Mahoney, S, Zimmerman, T S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303485/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2839543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113559
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