Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

A polarized layer of endothelial cells that comprises the blood–brain barrier (BBB) precludes access of systemically administered medicines to brain tissue. Consequently, there is a need for drug delivery vehicles that mediate transendothelial transport of such medicines. Endothelial cells use a var...

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Main Authors: Georgieva, Julia V, Kalicharan, Dharamdajal, Couraud, Pierre-Olivier, Romero, Ignacio A, Weksler, Babette, Hoekstra, Dick, Zuhorn, Inge S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034845/
https://ncbi.nlm.nih.gov/pubmed/21045812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.236
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