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Physicochemical Selectivity of the BBB Microenvironment Governing Passive Diffusion—Matching with a Porcine Brain Lipid Extract Artificial Membrane Permeability Model
PURPOSE: To mimic the physicochemical selectivity of the blood-brain barrier (BBB) and to predict its passive permeability using a PAMPA model based on porcine brain lipid extract (PBLE 10%w/v in alkane). METHODS: Three PAMPA (BD pre-coated and PBLE with 2 different lipid volumes) models were tested...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034772/ https://ncbi.nlm.nih.gov/pubmed/20945153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0280-x |
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