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Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfuro­coccus amylolyticus

Flap endonuclease 1 (FEN1) is a key enzyme in DNA repair and DNA replication. It is a structure-specific nuclease that removes 5′-overhanging flaps and the RNA/DNA primer during maturation of the Okazaki fragment. Homologues of FEN1 exist in a wide range of bacteria, archaea and eukaryotes. In order...

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Detalhes bibliográficos
Main Authors: Mase, Tomoko, Kubota, Keiko, Miyazono, Ken-ichi, Kawarabayasi, Yutaka, Tanokura, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034609/
https://ncbi.nlm.nih.gov/pubmed/21301087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110053030
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