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Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

We have recently reported that progeroid Zmpste24(−/−) mice, which exhibit multiple defects that phenocopy Hutchinson-Gilford progeria syndrome, show a profound dysregulation of somatotropic axis, mainly characterized by the occurrence of very high circulating levels of growth hormone (GH) and a dra...

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Detalhes bibliográficos
Main Authors: Ugalde, Alejandro P., Mariño, Guillermo, López-Otín, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034170/
https://ncbi.nlm.nih.gov/pubmed/21212467
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