Induction of the Intrinsic Apoptotic Pathway by 3-Deazaadenosine Is Mediated by BAX Activation in HL-60 Cells

3-Deazaadenosine (DZA), a potent inhibitor of S-adenosylhomocysteine hydrolase, was previously proposed to induce intrinsic apoptosis in human leukemic cells. In the present study, we analyzed the mechanism underlying the DZA-induced intrinsic apoptotic pathway. DZA activated typical caspase-depende...

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Autores principales: Lee, Sun-Young, Ko, Kyoung-Won, Kang, Won-Kyung, Choe, Yun-Jeong, Kim, Yoon-Hyoung, Kim, In-Kyung, Kim, Jin, Kim, Ho-Shik
Formato: Artigo
Lenguaje:Inglês
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034121/
https://ncbi.nlm.nih.gov/pubmed/21311682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2010.14.6.407
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