Phosphorylation of Human Cytomegalovirus Glycoprotein B (gB) at the Acidic Cluster Casein Kinase 2 Site (Ser(900)) Is Required for Localization of gB to the trans-Golgi Network and Efficient Virus Replication

Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified residue serine 900 (Ser(900)) as a unique site of reversible casein kinase 2 phosphorylation in the cytopla...

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Main Authors: Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., Baldick, Carl J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC303410/
https://ncbi.nlm.nih.gov/pubmed/14671110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.285-293.2004
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